Suppression of HSP27 increases the anti-tumor effects of quercetin in human leukemia U937 cells

  title={Suppression of HSP27 increases the anti-tumor effects of quercetin in human leukemia U937 cells},
  author={Xi Chen and Xiu-Shuai Dong and Hai-Yan Gao and Yong-fang Jiang and Ying-Lan Jin and Yu-Ying Chang and Li-yan Chen and Jing-Hua Wang},
  booktitle={Molecular medicine reports},
Quercetin, a natural flavonoid, inhibits the growth of leukemia cells and induces apoptosis. Heat shock protein 27 (HSP27) has been reported to promote the development of leukemia by protecting tumor cells from apoptosis through various mechanisms. The present study investigated the effects of small hairpin (sh)RNA-mediated HSP27 knockdown on the anti‑cancer effects of quercetin in U937 human leukemia cells. Cells were transfected with recombinant lentiviral vector pCMV‑G‑NR‑U6‑shHSP27 (shHSP27… CONTINUE READING
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