Suppression of HIV-specific T cell activity by lymph node CD25+ regulatory T cells from HIV-infected individuals.

@article{Kinter2007SuppressionOH,
  title={Suppression of HIV-specific T cell activity by lymph node CD25+ regulatory T cells from HIV-infected individuals.},
  author={Audrey L. Kinter and Jonathan P. McNally and Lindsey Riggin and Robert Owen Jackson and Gregg A Roby and Anthony S. Fauci},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 9},
  pages={3390-5}
}
CD25(+) CD4(+) FoxP3(+) regulatory T (Treg) cells isolated from the peripheral blood of asymptomatic HIV-infected individuals have been demonstrated to significantly suppress HIV-specific immune responses in vitro. CD25(+) Treg cell suppressor activity in the peripheral blood seems to diminish with progression of HIV disease, and it has been suggested that loss of Treg cells contributes to aberrant immune activation and disease progression. However, phenotypic studies suggest that Treg cells… CONTINUE READING
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