Suppression of HIV-1 plasma viral load below detection preserves IL-17 producing T cells in HIV-1 infection.

@article{Ndhlovu2008SuppressionOH,
  title={Suppression of HIV-1 plasma viral load below detection preserves IL-17 producing T cells in HIV-1 infection.},
  author={Lishomwa C. Ndhlovu and Joan M. Chapman and Aashish R. Jha and Jennifer E. Snyder-Cappione and Moraima Pagan and Fabio Leal and Brigid S. Boland and Phillip J Norris and Michael G. Rosenberg and Douglas F Nixon},
  journal={AIDS},
  year={2008},
  volume={22 8},
  pages={990-2}
}
IL-17 is proinflammatory cytokine secreted by a unique CD4+ T (Th17) cell subset and proposed to play a role in host defense. We hypothesized that Th17 cells are lost in HIV-1 infection. HIV-1-infected children with plasma viremia below 50 copies/ml had IL-17 production, whereas those with detectable viremia had minimal secretion. These results imply viral-mediated destruction or impairment of Th17 cells and argue for complete suppression of viremia for reconstitution of Th17 cells. 

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Efficacy and safety of TMC 125 ( etravirine ) in treatmentexperienced HIV1infected patients in DUET1 : 24 - week results from a randomised , double - blind , placebo - controlled trial

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