Suppression of HCV-specific T cells without differential hierarchy demonstrated ex vivo in persistent HCV infection.

@article{Sugimoto2003SuppressionOH,
  title={Suppression of HCV-specific T cells without differential hierarchy demonstrated ex vivo in persistent HCV infection.},
  author={Kazushi Sugimoto and Fusao Ikeda and Jason E Stadanlick and Frederick A. Nunes and Harvey J. Alter and K M Chang},
  journal={Hepatology},
  year={2003},
  volume={38 6},
  pages={1437-48}
}
Hepatitis C virus (HCV) has a high propensity for persistence. To better define the immunologic determinants of HCV clearance and persistence, we examined the circulating HCV-specific T-cell frequency, repertoire, and cytokine phenotype ex vivo in 24 HCV seropositive subjects (12 chronic, 12 recovered), using 361 overlapping peptides in 36 antigenic pools that span the entire HCV core, NS3-NS5. Consistent with T-cell-mediated control of HCV, the overall HCV-specific type-1 T-cell response was… CONTINUE READING