Suppression of GATA-3 Nuclear Import and Phosphorylation: A Novel Mechanism of Corticosteroid Action in Allergic Disease

@article{Maneechotesuwan2009SuppressionOG,
  title={Suppression of GATA-3 Nuclear Import and Phosphorylation: A Novel Mechanism of Corticosteroid Action in Allergic Disease},
  author={Kittipong Maneechotesuwan and Xin Yao and Kazuhiro Ito and Elen P I Jazrawi and Omar Sharif Usmani and Ian M. Adcock and Peter J Barnes},
  journal={PLoS Medicine},
  year={2009},
  volume={6},
  pages={238 - 255}
}
BACKGROUND GATA-3 plays a critical role in regulating the expression of the cytokines interleukin (IL)-4, IL-5, and IL-13 from T helper-2 (Th2) cells and therefore is a key mediator of allergic diseases. Corticosteroids are highly effective in suppressing allergic inflammation, but their effects on GATA-3 are unknown. We investigated the effect of the corticosteroid fluticasone propionate on GATA-3 regulation in human T-lymphocytes in vitro and in vivo. METHODS AND FINDINGS In a T lymphocyte… CONTINUE READING
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Glucocorticoid receptor nuclear translocation in airway cells following inhaled combination therapy

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