Suppression of Francisella tularensis growth in the rat by co-infection with F. novicida.

@article{Cowley1997SuppressionOF,
  title={Suppression of Francisella tularensis growth in the rat by co-infection with F. novicida.},
  author={Siobh{\'a}n C Cowley and S V Myltseva and Francis E Nano},
  journal={FEMS microbiology letters},
  year={1997},
  volume={153 1},
  pages={71-4}
}
We have previously shown that when cultured in vitro, peritoneal rat macrophages infected with Francisella novicida spontaneously release nitric oxide in sufficient quantities to inhibit bacterial growth. However, it is not known whether F. novicida can have a similar antimicrobial effect in vivo. Here we show that a co-infection of F. novicida with Francisella tularensis can suppress the number of F. tularensis cells in rat spleens by as much as 100-fold. 

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