Suppression of EGF-induced tumor cell migration and matrix metalloproteinase-9 expression by capsaicin via the inhibition of EGFR-mediated FAK/Akt, PKC/Raf/ERK, p38 MAPK, and AP-1 signaling.

@article{Hwang2011SuppressionOE,
  title={Suppression of EGF-induced tumor cell migration and matrix metalloproteinase-9 expression by capsaicin via the inhibition of EGFR-mediated FAK/Akt, PKC/Raf/ERK, p38 MAPK, and AP-1 signaling.},
  author={Yong Pil Hwang and Hyo Jeong Yun and Jae ho Choi and Eun Hee Han and Hyung Gyun Kim and Gye Yong Song and Kwang-il Kwon and Tae Cheon Jeong and Hye Gwang Jeong},
  journal={Molecular nutrition \& food research},
  year={2011},
  volume={55 4},
  pages={
          594-605
        }
}
SCOPE Capsaicin is a cancer-suppressing agent. The aim of our study was to determine the effect of capsaicin on tumor invasion and migration; the possible mechanisms involved in this inhibition were investigated in human fibrosarcoma cells. METHODS AND RESULTS We employed invasion, migration and gelatin zymography assays to characterize the effect of capsaicin on HT-1080 cells. Transient transfection assays and immunoblot analysis were performed to study its molecular mechanisms of action… Expand
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