Suppression of Drug Resistance in Dengue Virus

Abstract

UNLABELLED Dengue virus is a major human pathogen responsible for 400 million infections yearly. As with other RNA viruses, daunting challenges to antiviral design exist due to the high error rates of RNA-dependent RNA synthesis. Indeed, treatment of dengue virus infection with a nucleoside analog resulted in the expected genetic selection of resistant… (More)
DOI: 10.1128/mBio.01960-15

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