Suppression of Cell Proliferation by Inhibition of Estrone-3-Sulfate Transporter in Estrogen-Dependent Breast Cancer Cells

@article{Nozawa2005SuppressionOC,
  title={Suppression of Cell Proliferation by Inhibition of Estrone-3-Sulfate Transporter in Estrogen-Dependent Breast Cancer Cells},
  author={Takashi Nozawa and Masataka Nakazawa and Hikaru Yabuuchi and Masanori Irokawa and Akira Tsuji and Ikumi Tamai},
  journal={Pharmaceutical Research},
  year={2005},
  volume={22},
  pages={1634-1641}
}
The aim of the study is to suppress the progress of estrogen-dependent breast cancer by inhibiting the membrane transporter, which mediates the internalization of estrone-3-sulfate as estrogen precursor in the cancer cells. The uptake of estrone-3-sulfate by estrogen-dependent breast cancer MCF-7 cells was measured, and inhibitory study using various organic anions on estrone-3-sulfate uptake by MCF-7 cells was conducted. The effects of the inhibitor on the transcription of reporter gene and… CONTINUE READING