Suppression of Cell-Mediated Immunity following Recognition of Phagosome-Confined Bacteria

  title={Suppression of Cell-Mediated Immunity following Recognition of Phagosome-Confined Bacteria},
  author={Keith S. Bahjat and Nicole P Meyer-Morse and Edward E. Lemmens and Jessica A. Shugart and Thomas W Dubensky and Dirk G. Brockstedt and Daniel A Portnoy},
  booktitle={PLoS pathogens},
Listeria monocytogenes is a facultative intracellular pathogen capable of inducing a robust cell-mediated immune response to sub-lethal infection. The capacity of L. monocytogenes to escape from the phagosome and enter the host cell cytosol is paramount for the induction of long-lived CD8 T cell-mediated protective immunity. Here, we show that the impaired T cell response to L. monocytogenes confined within a phagosome is not merely a consequence of inefficient antigen presentation, but is the… CONTINUE READING
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