Suppression of Ca2+ syntillas increases spontaneous exocytosis in mouse adrenal chromaffin cells


A central concept in the physiology of neurosecretion is that a rise in cytosolic [Ca(2+)] in the vicinity of plasmalemmal Ca(2+) channels due to Ca(2+) influx elicits exocytosis. Here, we examine the effect on spontaneous exocytosis of a rise in focal cytosolic [Ca(2+)] in the vicinity of ryanodine receptors (RYRs) due to release from internal stores in… (More)
DOI: 10.1085/jgp.200910285


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