Suppression of CD4+ T lymphocyte effector functions by CD4+CD25+ cells in vivo.


CD4+CD25+ regulatory T cells have been extensively studied during the last decade, but how these cells exert their regulatory function on pathogenic effector T cells remains to be elucidated. Naive CD4+ T cells transferred into T cell-deficient mice strongly expand and rapidly induce inflammatory bowel disease (IBD). Onset of this inflammatory disorder depends on IFN-gamma production by expanding CD4+ T cells. Coinjection of CD4+CD25+ regulatory T cells protects recipient mice from IBD. In this study, we show that CD4+CD25+ regulatory T cells do not affect the initial activation/proliferation of injected naive T cells as well as their differentiation into Th1 effectors. Moreover, naive T cells injected together with CD4+CD25+ regulatory T cells into lymphopenic hosts are still able to respond to stimuli in vitro when regulatory T cells are removed. In these conditions, they produce as much IFN-gamma as before injection or when injected alone. Finally, when purified, they are able to induce IBD upon reinjection into lymphopenic hosts. Thus, prevention of IBD by CD4+CD25+ regulatory T cells is not due to deletion of pathogenic T cells, induction of a non reactive state (anergy) among pathogenic effector T cells, or preferential induction of Th2 effectors rather than Th1 effectors; rather, it results from suppression of T lymphocyte effector functions, leading to regulated responses to self.

8 Figures and Tables


Citations per Year

449 Citations

Semantic Scholar estimates that this publication has 449 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Martin2004SuppressionOC, title={Suppression of CD4+ T lymphocyte effector functions by CD4+CD25+ cells in vivo.}, author={Bruno Martin and Alice Banz and B Bienvenu and Corinne Cordier and Nicole Dautigny and Chantal B{\'e}court and Bruno Lucas}, journal={Journal of immunology}, year={2004}, volume={172 6}, pages={3391-8} }