Suppression of Autoimmune Retinal Inflammation by an Antiangiogenic Drug

@inproceedings{Yoshimura2013SuppressionOA,
  title={Suppression of Autoimmune Retinal Inflammation by an Antiangiogenic Drug},
  author={Takeru Yoshimura and Ofra Benny and Lauren Bazinet and Robert J. D’Amato},
  booktitle={PloS one},
  year={2013}
}
Chronic and recurrent uveitis account for approximately 10% of legal blindness in the western world. Autoimmune uveitis is driven by activated CD4(+) T cells that differentiate into effector T helper cells (Th1, Th2, and Th17) which release proinflammatory cytokines that damage the retina. In this study we investigated the effect of the methionine aminopeptidase 2 (MetAP2) inhibitor, Lodamin, on T cell activation and differentiation. MetAp2 is an enzyme which regulates cellular protein… CONTINUE READING