Suppression of Alzheimer-associated inflammation by microglial prostaglandin-E2 EP4 receptor signaling.

@article{Woodling2014SuppressionOA,
  title={Suppression of Alzheimer-associated inflammation by microglial prostaglandin-E2 EP4 receptor signaling.},
  author={Nathaniel S Woodling and Qian Wang and Prachi G Priyam and Paul Larkin and Ju Shi and Jenny Ulrika Johansson and Ir{\`e}ne Zagol-Ikapitte and Olivier Boutaud and Katrin I. Andreasson},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2014},
  volume={34 17},
  pages={5882-94}
}
A persistent and nonresolving inflammatory response to accumulating Aβ peptide species is a cardinal feature in the development of Alzheimer's disease (AD). In response to accumulating Aβ peptide species, microglia, the innate immune cells of the brain, generate a toxic inflammatory response that accelerates synaptic and neuronal injury. Many proinflammatory signaling pathways are linked to progression of neurodegeneration. However, endogenous anti-inflammatory pathways capable of suppressing A… CONTINUE READING
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