Suppression of Akt-HIF-1α signaling axis by diacetyl atractylodiol inhibits hypoxia-induced angiogenesis

@inproceedings{Choi2016SuppressionOA,
  title={Suppression of Akt-HIF-1α signaling axis by diacetyl atractylodiol inhibits hypoxia-induced angiogenesis},
  author={Sik-Won Choi and Kwang-Sik Lee and Jin Hwan Lee and Hyeon Jung Kang and Mi Ja Lee and Hyun Young Kim and Kie-In Park and Sun Lim Kim and Hye Kyoung Shin and Woo Duck Seo},
  booktitle={BMB reports},
  year={2016}
}
Hypoxia-inducible factor (HIF)-1α is a key regulator associated with tumorigenesis, angiogenesis, and metastasis. HIF-1α regulation under hypoxia has been highlighted as a promising therapeutic target in angiogenesis-related diseases. Here, we demonstrate that diacetyl atractylodiol (DAA) from Atractylodes japonica (A. japonica) is a potent HIF-1α inhibitor… CONTINUE READING