Suppression of 5'-AMP-activated protein kinase activity does not impair recovery of contractile function during reperfusion of ischemic hearts.

@article{Folmes2009SuppressionO5,
  title={Suppression of 5'-AMP-activated protein kinase activity does not impair recovery of contractile function during reperfusion of ischemic hearts.},
  author={Clifford D. L. Folmes and Cory S. Wagg and Mei Shen and Alexander A S C Clanachan and Rong Tian and Gary D Lopaschuk},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2009},
  volume={297 1},
  pages={H313-21}
}
Activation of 5'-AMP-activated protein kinase (AMPK) may benefit the heart during ischemia-reperfusion by increasing energy production. While AMPK stimulates glycolysis, mitochondrial oxidative metabolism is the major source of ATP production during reperfusion of ischemic hearts. Stimulating AMPK increases mitochondrial fatty acid oxidation, but this is usually accompanied by a decrease in glucose oxidation, which can impair the functional recovery of ischemic hearts. To examine the… CONTINUE READING

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