Suppression by memantine and amantadine of synaptic excitation intrastriatally evoked in rat neostriatal slices.

@article{Rohrbacher1994SuppressionBM,
  title={Suppression by memantine and amantadine of synaptic excitation intrastriatally evoked in rat neostriatal slices.},
  author={J Rohrbacher and Maria Bijak and Ulrich Misgeld},
  journal={Neuroscience letters},
  year={1994},
  volume={182 1},
  pages={95-8}
}
The competitive N-methyl-D-aspartate (NMDA) receptor antagonists, DL-(E)-2-amino-4-methyl-5-phosphono-3-pentanoic acid (CGP 37849) and D(-)-2-amino-5-phosphonovaleric acid (APV), and the non-competitive NMDA antagonists, memantine and amantadine, which are used in the treatment of Parkinson's disease, were tested for their effects on intrastriatally evoked excitatory postsynaptic potentials (EPSPs) in rat neostriatal slices. Fast, non-NMDA receptor mediated synaptic excitation was not affected… CONTINUE READING