Suppression by gabapentin of pain-related mechano-responses in mice given orthotopic tumor inoculation.

@article{Kuraishi2003SuppressionBG,
  title={Suppression by gabapentin of pain-related mechano-responses in mice given orthotopic tumor inoculation.},
  author={Yasushi Kuraishi and Yoshitaka Iida and Hong-wei Zhang and Saori Uehara and Hiroshi Nojima and Jun Murata and Ikuno Saiki and Hiroki Takahata and Hidekazu Ouchi},
  journal={Biological & pharmaceutical bulletin},
  year={2003},
  volume={26 4},
  pages={
          550-2
        }
}
In this study, we examined whether several types of non-opioid agents would inhibit the pain-related responses of melanoma-bearing mice. Orthotopic inoculation with melanoma into the hind paw induced marked tactile allodynia and mechanical hyperalgesia. A peroral injection (p.o.) of gabapentin (100-300 mg/kg) inhibited the allodynia and hyperalgesia, without effects on gross behaviors. An intraperitoneal injection (i.p.) of ketamine hydrochloride (30 mg/kg) produced partial inhibition in… CONTINUE READING

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