Suppression by baclofen of alcohol deprivation effect in Sardinian alcohol-preferring (sP) rats.

@article{Colombo2003SuppressionBB,
  title={Suppression by baclofen of alcohol deprivation effect in Sardinian alcohol-preferring (sP) rats.},
  author={Giancarlo Colombo and Salvatore Serra and Giuliana Brunetti and Giovanni Vacca and Mauro A. M. Carai and Gian Luigi Gessa},
  journal={Drug and alcohol dependence},
  year={2003},
  volume={70 1},
  pages={
          105-8
        }
}
Alcohol deprivation effect (ADE), i.e. the transient increase in alcohol intake that takes place in laboratory animals after a period of alcohol deprivation, has been proposed to model alcohol relapses in alcoholics. The present study investigated the effect of the GABA(B) receptor agonist, baclofen, on the development of ADE in selectively bred Sardinian alcohol-preferring (sP) rats. Acute administration of non-sedative doses of baclofen (0, 1, 1.7 and 3 mg/kg, i.p.) resulted in the complete… CONTINUE READING
BETA

Similar Papers

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 48 CITATIONS

Suppressing Effect of Baclofen on Multiple Alcohol-Related Behaviors in Laboratory Animals

  • Front. Psychiatry
  • 2018
VIEW 4 EXCERPTS
CITES BACKGROUND, METHODS & RESULTS
HIGHLY INFLUENCED

Baclofen alters flash-evoked potentials in Long–Evans rats

  • Pharmacology Biochemistry and Behavior
  • 2007
VIEW 2 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED