Suppression by apigenin of peritoneal metastasis of intestinal adenocarcinomas induced by azoxymethane in Wistar rats

@article{Tatsuta2004SuppressionBA,
  title={Suppression by apigenin of peritoneal metastasis of intestinal adenocarcinomas induced by azoxymethane in Wistar rats},
  author={M. Tatsuta and H. Iishi and M. Baba and H. Yano and K. Murata and M. Mukai and H. Akedo},
  journal={Clinical \& Experimental Metastasis},
  year={2004},
  volume={18},
  pages={657-662}
}
The effect of a naturally occurring flavonoid apigenin on the development of bombesin-enhanced peritoneal metastasis from intestinal adenocarcinomas induced by azoxymethane was investigated in male Wistar rats. From the start of the experiment, rats were given weekly s.c. injections of azoxymethane (7.4 mg/kg body weight) for 10 weeks and s.c. injection of bombesin (40 μg/kg body weight) every other day, and from week 16, s.c. injections of apigenin (0.75 or 1.5 mg/kg body weight) every other… Expand
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