Suppression and regression of choroidal neovascularization by polyamine analogues.

  title={Suppression and regression of choroidal neovascularization by polyamine analogues.},
  author={Raquel Lima e Silva and Yoshitsugu Saishin and Yumiko Saishin and Hideo Akiyama and Shu Kachi and Sadia Aslam and Brian Rogers and Tye G. Deering and Yuan Yuan Gong and Sean Francis Hackett and Hong Shiee Lai and Benjamin J Frydman and Aldonia L. Valasinas and Laurence J. Marton and Peter Anthony Campochiaro},
  journal={Investigative ophthalmology & visual science},
  volume={46 9},
PURPOSE Polyamine analogues inhibit tumor growth in vitro and in vivo, and oligoamines with a chain length of 10, 12, or 14 are particularly potent. This study was conducted to investigate the effect of the decamines CGC-11144 and CGC-11150 in a mouse model of choroidal neovascularization (CNV). METHODS Mice with laser-induced rupture of Bruch's membrane… CONTINUE READING