Suppressing the morning rise in cortisol impairs free recall.

  title={Suppressing the morning rise in cortisol impairs free recall.},
  author={Ulrike Rimmele and Flurina Meier and Tanja Lange and Jan Born},
  journal={Learning & memory},
  volume={17 4},
Elevated glucocorticoid levels impair memory retrieval. We investigated whether retrieval under naturally elevated glucocorticoid levels, i.e., during the morning rise in cortisol can be improved by suppressing cortisol. In a crossover study 16 men retrieved emotional and neutral texts and pictures (learned 3 d earlier) 30 min after morning awakening, following administration of the cortisol synthesis inhibitor metyrapone or placebo. Unexpectedly, the metyrapone-induced cortisol suppression… CONTINUE READING


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Preventive effect of b-adrenoceptor blockade on glucocorticoid-induced memory retrieval deficits

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