Suppressing the CRISPR/Cas adaptive immune system in bacterial infections

  title={Suppressing the CRISPR/Cas adaptive immune system in bacterial infections},
  author={Pourya Gholizadeh and Mohammad Hossein Aghazadeh and Mohammad Asgharzadeh and Hossein Samadi Kafil},
  journal={European Journal of Clinical Microbiology \& Infectious Diseases},
Clustered regularly interspaced short palindromic repeats (CRISPR) coupled with CRISPR-associated (Cas) proteins (CRISPR/Cas) are the adaptive immune system of eubacteria and archaebacteria. [] Key Result These results showed that the CRISPR/Cas system might prevent the emergence of virulence both in vitro and in vivo. Moreover, this system was shown to be a strong selective pressure for the acquisition of antibiotic resistance and virulence factor in bacterial pathogens.

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The Streptococcus thermophilus CRISPR/Cas system provides immunity in Escherichia coli

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CRISPR-based adaptive and heritable immunity in prokaryotes.

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