Suppressing role of transforming growth factor-beta 1 on cathepsin activity in cultured kidney tubule cells.

@article{Ling1995SuppressingRO,
  title={Suppressing role of transforming growth factor-beta 1 on cathepsin activity in cultured kidney tubule cells.},
  author={Huaiping Ling and Spyridon Vamvakas and Gabi Busch and Jobst D{\"a}mmrich and Lothar Schramm and Florian Lang and August Heidland},
  journal={The American journal of physiology},
  year={1995},
  volume={269 6 Pt 2},
  pages={F911-7}
}
Elevated expression and activity of transforming growth factor-beta 1 (TGF-beta 1) have been indicated in various renal diseases, implicating the potential involvement of this growth factor in the accumulation of extracellular matrix. To assess its potential role on protein turnover in tubule cells, we investigated in LLC-PK1 cells the effects of TGF-beta 1 on the activities of lysosomal cysteine proteinases cathepsins B, H, and L + B, which play a major role in the degradation of both cellular… CONTINUE READING