Suppressing effects of glucan on micronuclei induced by cyclophosphamide in mice.

@article{Chorvatovicov1992SuppressingEO,
  title={Suppressing effects of glucan on micronuclei induced by cyclophosphamide in mice.},
  author={D Chorvatovicov{\'a} and Jana Navarov{\'a}},
  journal={Mutation research},
  year={1992},
  volume={282 3},
  pages={147-50}
}
The effect of pretreatment with carboxymethylglucan (CMG) on the frequency of micronuclei induced by cyclophosphamide administration in mice was evaluated. Two doses of CMG (50 mg/kg body weight) injected either intraperitoneally 24 h or intravenously 1 h prior to two cyclophosphamide administrations (80 mg/kg) significantly decreased the frequency of micronucleated PCE in bone marrow. Of two evaluated derivatives of carboxymethylglucan, the K3 derivative was most efficient. The results show… CONTINUE READING