Suppressing Pitx2 inhibits proliferation and promotes differentiation of iHepSCs.

@article{Song2016SuppressingPI,
  title={Suppressing Pitx2 inhibits proliferation and promotes differentiation of iHepSCs.},
  author={Erwei Song and Hao Yao and Minjun Wang and Bing Yu and Qinggui Liu and Jianxiu Li and Zhiying He and Yi-Ping Hu},
  journal={The international journal of biochemistry & cell biology},
  year={2016},
  volume={80},
  pages={154-162}
}
Induced hepatic stem cells (iHepSCs) have great potential as donors for liver cell therapy due to their abilities for self-renewal and bi-potential differentiation. However, the molecular mechanism regulating proliferation and differentiation of iHepSCs is poorly understood. In this study, we provide evidence that the homeodomain transcription factor, Pitx2… CONTINUE READING