Suppressing IL-32 in monocytes impairs the induction of the proinflammatory cytokines TNFalpha and IL-1beta.

@article{Hong2010SuppressingII,
  title={Suppressing IL-32 in monocytes impairs the induction of the proinflammatory cytokines TNFalpha and IL-1beta.},
  author={Jaewoo Hong and Suyoung Bae and Youngsun Kang and Doyoung Yoon and Xiyuan Bai and Edward D. Chan and Tania Azam and Charles A Dinarello and Siyoung Lee and Erk Her and Gyujin Rho and Soohyun Kim},
  journal={Cytokine},
  year={2010},
  volume={49 2},
  pages={171-6}
}
Targeting major proinflammatory cytokines such as IL-1beta and TNFalpha is of great interest in patients with chronic inflammatory diseases, including rheumatoid arthritis, colitis, and psoriasis. The cytokine Interleukin (IL)-32 induces proinflammatory cytokines such as TNFalpha, IL-1beta, IL-6, and chemokines. We previously used an IL-32 ligand-affinity column to purify proteinase 3, which is abundantly expressed in neutrophil and monocytic leukocytes but not in other cell types, and found… CONTINUE READING