Suppressing Effect of Baclofen on Multiple Alcohol-Related Behaviors in Laboratory Animals

@inproceedings{Colombo2018SuppressingEO,
  title={Suppressing Effect of Baclofen on Multiple Alcohol-Related Behaviors in Laboratory Animals},
  author={Giancarlo Colombo and Gian Luigi Gessa},
  booktitle={Front. Psychiatry},
  year={2018}
}
This paper summarizes the several lines of experimental evidence demonstrating the ability of the prototypic GABAB receptor agonist, baclofen, to suppress multiple alcohol-related behaviors in laboratory rodents and non-human primates exposed to validated experimental models of alcohol use disorder (AUD). Specifically, treatment with baclofen has repeatedly been reported to suppress alcohol-induced locomotor stimulation, alcohol drinking (including binge- and relapse-like drinking), operant… CONTINUE READING
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