Suppressed recruitment of alternatively activated macrophages reduces TGF-β1 and impairs wound healing in streptozotocin-induced diabetic mice.

@article{Okizaki2015SuppressedRO,
  title={Suppressed recruitment of alternatively activated macrophages reduces TGF-β1 and impairs wound healing in streptozotocin-induced diabetic mice.},
  author={Shin-ichiro Okizaki and Yoshiya Ito and Kanako Hosono and Kazuhito Oba and Hirotoki Ohkubo and Hideki Amano and Masayoshi Shichiri and Masataka C Majima},
  journal={Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie},
  year={2015},
  volume={70},
  pages={317-25}
}
BACKGROUND Diabetes mellitus inhibits wound-induced angiogenesis, impairing the wound healing process and leading to the development of chronic wounds. Impaired healing of diabetic wounds is caused by persistent pro-inflammatory macrophages recruited to the granulation tissue; however, little is known about the phenotype of the macrophages involved in diabetic wound healing. The present study was conducted to examine the involvement of macrophages in impaired wound healing using streptozotocin… CONTINUE READING