Suppressed neuropeptide Y (NPY) mRNA in rat amygdala following restraint stress.

  title={Suppressed neuropeptide Y (NPY) mRNA in rat amygdala following restraint stress.},
  author={A G Thorsell and Peter Svensson and Lars Wiklund and Wolfgang Sommer and Rolf Ekman and Markus Heilig},
  journal={Regulatory peptides},
We have previously demonstrated that NPY produces anxiolytic-like effects through actions in the amygdala, and that anxiogenic-like effects of restraint stress are mediated through this structure. Here, we examined the effects of restraint stress on NPY mRNA levels in amygdala and several other brain regions. A sensitive solution hybridization-RNase protection assay (RPA) was developed, employing a combination of internal and external standards, which allowed absolute quantitation of NPY mRNA… CONTINUE READING


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