Suppressed gap junctional intercellular communication in carcinogenesis of endometrium.

@article{Saito2001SuppressedGJ,
  title={Suppressed gap junctional intercellular communication in carcinogenesis of endometrium.},
  author={Tsuyoshi Saito and Makoto Nishimura and Ryuichi Kudo and Hiroshi Yamasaki},
  journal={International journal of cancer},
  year={2001},
  volume={93 3},
  pages={317-23}
}
To examine whether and at which stage of endometrial carcinogenesis decreased connexin expression occurs, we investigated changes in the expression of the gap junction proteins, connexin 26 (Cx26), Cx32 and Cx43, in human endometrial hyperplasia and cancer samples. Forty-eight endometrial tissue samples (15 endometrial hyperplasias and 33 endometrial cancers) were subjected to immunofluorescence and RT-PCR analysis. In endometrial hyperplasia, Cx26 was aberrantly expressed in all samples as… CONTINUE READING

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