Suppressed fever and hypersensitivity responses in chicks prenatally exposed to opiates

  title={Suppressed fever and hypersensitivity responses in chicks prenatally exposed to opiates},
  author={L. Schrott and S. Sparber},
  journal={Brain, Behavior, and Immunity},
  • L. Schrott, S. Sparber
  • Published 2004
  • Biology, Medicine
  • Brain, Behavior, and Immunity
  • We have established procedures to reliably induce opiate dependence in the chick embryo via in ovo injection, early in embryonic development, of the long-acting and potent opiate N-desmethyl-l-alpha-noracetylmethadol (NLAAM). Prior studies found that there is continual exposure to NLAAM throughout embryogenesis and shortly after hatching there are signs of spontaneous withdrawal. In the present study, we used three doses of NLAAM (2.5, 5, and 10 mg/kg egg weight) to determine if prenatal opiate… CONTINUE READING
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