Suppressed diversity of survivin splicing in active rheumatoid arthritis.

INTRODUCTION Alternative splicing distinguishes normal and pathologic cells. High levels of oncoprotein survivin recognise patients with severe rheumatoid arthritis (RA). Here, we assess clinical relevance of alternative splicing of survivin in leukocytes of peripheral blood (PBMC) and bone marrow (BM) in RA patients. METHOD Transcription of survivin wild… CONTINUE READING