Suppressed cellular immunity in mice harboring intraocular melanomas.

  title={Suppressed cellular immunity in mice harboring intraocular melanomas.},
  author={Jerry Y. Niederkorn},
  journal={Investigative ophthalmology & visual science},
  volume={25 4},
Intracameral (IC) inoculation of syngeneic B16F10 melanoma cells into the anterior chamber of C57BL/6 mice evoked specific impairment of delayed-type hypersensitivity (DTH) responses, yet stimulated significant humoral antibody production. However, the presence of anti-melanoma antibodies did not protect against progressive tumor growth. In contrast to the results with intracameral inoculations, subcutaneous injection of B16F10 melanoma cells induced significant DTH responsiveness in C57BL/6… CONTINUE READING
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Immunologic evaluation of spontaneous regression of an intraocular murine melanoma.

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