Support of Homeostatic Glial Cell Signaling: A Novel Therapeutic Approach by Propentofylline a

@article{Schubert1997SupportOH,
  title={Support of Homeostatic Glial Cell Signaling: A Novel Therapeutic Approach by Propentofylline a},
  author={P. Schubert and T. Ogata and K. Rudolphi and C. Marchini and A. McRae and S. Ferroni},
  journal={Annals of the New York Academy of Sciences},
  year={1997},
  volume={826}
}
ABSTRACT: A pathological glial cell activation, which forces microglia to transform into immunocompetent cells with cytotoxic properties and astrocytes to “dedifferentiate,” presumably adds to neurodegenerative diseases. We examined the modulatory effect of adenosine on the Ca2+ and cAMP‐dependent regulation of such reactive glial cell properties in culture and tested possibilities of pharmacologic reinforcement. A strengthening of the cAMP‐signaling, as could be achieved by adenosine agonists… Expand
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