Support for the vascular depression hypothesis in late-life depression: results of a 2-site, prospective, antidepressant treatment trial.

@article{Sheline2010SupportFT,
  title={Support for the vascular depression hypothesis in late-life depression: results of a 2-site, prospective, antidepressant treatment trial.},
  author={Yvette I. Sheline and Carl F. Pieper and Deanna M. Barch and Kathleen Welsh-Bohmer and Robert C. McKinstry and James R. MacFall and Gina D'Angelo and Keith S. Garcia and Kenneth Gersing and Consuelo H. Wilkins and Warren Taylor and David C. Steffens and Ranga K. R. Krishnan and P. Murali Doraiswamy},
  journal={Archives of general psychiatry},
  year={2010},
  volume={67 3},
  pages={277-85}
}
CONTEXT Research on vascular depression has used 2 approaches to subtype late-life depression, based on executive dysfunction or white matter hyperintensity severity. OBJECTIVE To evaluate the relationship of neuropsychological performance and white matter hyperintensity with clinical response in late-life depression. DESIGN Two-site, prospective, nonrandomized controlled trial. SETTING Outpatient clinics at Washington University and Duke University. PARTICIPANTS A total of 217 subjects… CONTINUE READING
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