Support for the involvement of large copy number variants in the pathogenesis of schizophrenia.

@article{Kirov2009SupportFT,
  title={Support for the involvement of large copy number variants in the pathogenesis of schizophrenia.},
  author={George G Kirov and Detelina Grozeva and Nadine Norton and Dobril K. Ivanov and Kiran Kumar Mantripragada and Peter Holmans and Nick J. Craddock and Michael J Owen and Michael C O'Donovan},
  journal={Human molecular genetics},
  year={2009},
  volume={18 8},
  pages={1497-503}
}
We investigated the involvement of rare (<1%) copy number variants (CNVs) in 471 cases of schizophrenia and 2792 controls that had been genotyped using the Affymetrix GeneChip 500K Mapping Array. Large CNVs >1 Mb were 2.26 times more common in cases (P = 0.00027), with the effect coming mostly from deletions (odds ratio, OR = 4.53, P = 0.00013) although duplications were also more common (OR = 1.71, P = 0.04). Two large deletions were found in two cases each, but in no controls: a deletion at… CONTINUE READING