Support for the homeobox transcription factor gene ENGRAILED 2 as an autism spectrum disorder susceptibility locus.

@article{Benayed2005SupportFT,
  title={Support for the homeobox transcription factor gene ENGRAILED 2 as an autism spectrum disorder susceptibility locus.},
  author={Rym Benayed and Neda Gharani and Ian T Rossman and Vincent Mancuso and Gloria S Lazar and Silky Kamdar and Shannon E Bruse and Samuel Tischfield and Brett A. Smith and Raymond A Zimmerman and Emanuel Dicicco-Bloom and Linda Brzustowicz and James H. Millonig},
  journal={American journal of human genetics},
  year={2005},
  volume={77 5},
  pages={851-68}
}
Our previous research involving 167 nuclear families from the Autism Genetic Resource Exchange (AGRE) demonstrated that two intronic SNPs, rs1861972 and rs1861973, in the homeodomain transcription factor gene ENGRAILED 2 (EN2) are significantly associated with autism spectrum disorder (ASD). In this study, significant replication of association for rs1861972 and rs1861973 is reported for two additional data sets: an independent set of 222 AGRE families (rs1861972-rs1861973 haplotype, P=.0016… CONTINUE READING