Support for genetic variation in neuregulin 1 and susceptibility to schizophrenia

@article{Williams2003SupportFG,
  title={Support for genetic variation in neuregulin 1 and susceptibility to schizophrenia},
  author={Nigel Melville Williams and Anna C Preece and Gillian Spurlock and Nadine Norton and Hywel J Williams and Stanley Zammit and Michael C O'Donovan and Michael J Owen},
  journal={Molecular Psychiatry},
  year={2003},
  volume={8},
  pages={485-487}
}
Recently, it has been reported that genetic variants around the gene neuregulin 1 are associated with schizophrenia in an Icelandic sample. Of particular interest was the presence of a single-risk haplotype that was significantly over-represented in schizophrenic individuals compared to controls (15.4 : 7.5%, P=6.7 × 10−6). We have attempted to replicate this result in our large collection of 573 schizophrenia cases and 618 controls. We found that the risk haplotype was more common in cases… CONTINUE READING
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