Support Vector Machine (SVM) Models for Predicting Inhibitors of the 3' Processing Step of HIV-1 Integrase.

Abstract

Inhibition of the 3' processing step of HIV-1 integrase by small molecule inhibitors is one of the most promising strategies for the treatment of AIDS. Using a support vector machine (SVM) approach, we developed six classification models for predicting 3'P inhibitors. The models are based on up to 48 selected molecular descriptors and a comprehensive data… (More)
DOI: 10.1002/minf.201300107

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