Supply-to-demand ratio for oxygen determines formation of adenosine by the heart.

@article{Bardenheuer1986SupplytodemandRF,
  title={Supply-to-demand ratio for oxygen determines formation of adenosine by the heart.},
  author={H. Bardenheuer and Jurgen Schrader},
  journal={The American journal of physiology},
  year={1986},
  volume={250 2 Pt 2},
  pages={H173-80}
}
To investigate the basic mechanism for formation of adenosine, cardiac work was increased using an isolated guinea pig working heart preparation. Cardiac metabolism was stimulated by intracoronary infusion of isoproterenol, norepinephrine (NE), ouabain, and the cardiotonic agent 1H-imidazo[4,5-b]pyridine, 2-[2-methoxy-4-(methylsulfinyl)-phenyl] (AR-L 115), and the release of adenosine into the effluent was determined. Besides their inotropic effects on myocardial tissue, these substances affect… CONTINUE READING
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