Supplementing mesenchymal stem cells improves the therapeutic effect of hematopoietic stem cell transplantation in the treatment of murine systemic lupus erythematosus.

@article{Liu2014SupplementingMS,
  title={Supplementing mesenchymal stem cells improves the therapeutic effect of hematopoietic stem cell transplantation in the treatment of murine systemic lupus erythematosus.},
  author={R H Liu and Yan-mi Li and Wan-jun Zhou and Y J Shi and Liansong Ni and Guipeng Liu},
  journal={Transplantation proceedings},
  year={2014},
  volume={46 5},
  pages={1621-7}
}
Transplantation of hematopoietic stem cells (HSCs) has been demonstrated to be a promising strategy in the treatment of systemic lupus erythematosus (SLE). Mesenchymal stem cells (MSCs) support hematopoiesis of HSCs and suppress immune response in a dose-dependent manner. Previous study showed that MSCs could alleviate the pathologic conditions of MRL/lpr mice (SLE animal model) when cotransplanted with bone marrow cells. Here, we investigated whether MSCs could improve the therapeutic effect… CONTINUE READING