Supplementation with goldenseal (Hydrastis canadensis), but not kava kava (Piper methysticum), inhibits human CYP3A activity in vivo.

@article{Gurley2008SupplementationWG,
  title={Supplementation with goldenseal (Hydrastis canadensis), but not kava kava (Piper methysticum), inhibits human CYP3A activity in vivo.},
  author={Bill Gurley and Ashley Swain and Martha A Hubbard and Faith Hartsfield and John J. Thaden and Diarria Williams and William Brooks Gentry and Yudong Tong},
  journal={Clinical pharmacology and therapeutics},
  year={2008},
  volume={83 1},
  pages={
          61-9
        }
}
The effects of goldenseal (Hydrastis canadensis) and kava kava (Piper methysticum) supplementation on human CYP3A activity were evaluated using midazolam (MDZ) as a phenotypic probe. Sixteen healthy volunteers were randomly assigned to receive either goldenseal or kava kava for 14 days. Each supplementation phase was followed by a 30-day washout period. MDZ (8 mg, per os) was administered before and after each phase, and pharmacokinetic parameters were determined using standard non… CONTINUE READING
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