Supplementation with cholecalciferol does not improve glycaemic control in diabetic subjects with normal serum 25-hydroxyvitamin D levels

@article{Jorde2009SupplementationWC,
  title={Supplementation with cholecalciferol does not improve glycaemic control in diabetic subjects with normal serum 25-hydroxyvitamin D levels},
  author={Rolf Jorde and Yngve Figenschau},
  journal={European Journal of Nutrition},
  year={2009},
  volume={48},
  pages={349-354}
}
BackgroundStudies have suggested that vitamin D may be important for both insulin sensitivity and insulin secretion, and that supplementation with vitamin D may subsequently prevent development of type 2 diabetes.Aim of the studyThe objective of the current study was to test the hypothesis that supplementation with vitamin D would improve glycaemic control in subjects with type 2 diabetes.MethodsThirty-six subjects with type 2 diabetes, treated with metformin and bed-time insulin, were… Expand
High-Dose Vitamin D Supplementation in People With Prediabetes and Hypovitaminosis D
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The Effect of Vitamin D Supplementation on Glycemic Control and Lipid Profile in Patients with Type 2 Diabetes Mellitus
TLDR
Vitamin D supplementation may be beneficial to diabetic subjects because it improved glycemic control and lipid profile levels and participants in a higher percentile had a significantly higher level of high-density lipoprotein cholesterol (HDL-C) than those in the middle percentile. Expand
Vitamin D3 supplementation improves glycemic control in type 2 diabetic patients: Results from an Italian clinical trial.
  • G. Derosa, A. D'angelo, +4 authors P. Maffioli
  • Medicine
  • International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition
  • 2020
TLDR
In type 2 diabetic patients with Vitamin D deficiency, the restoration of value in the Vitamin D standard has led not only to an improvement in the glyco-metabolic compensation, but also to a reduced posology of some oral hypoglycemic agents and some types of insulin used. Expand
Vitamin D deficiency is associated with insulin resistance in nondiabetics and reduced insulin production in type 2 diabetics.
TLDR
It was found that serum 25(OH)D was inversely associated with insulin resistance, and vitamin D deficiency is associated withulin resistance in nondiabetics, which is independent of obesity. Expand
Effect of Vitamin D Replacement on Insulin Sensitivity in Subjects With Vitamin D Deficiency
TLDR
Administration of ergocalciferol, 50,000 units, weekly for 8 weeks in subjects with low vitamin D levels improves 25(OH)D levels but does not improve insulin sensitivity. Expand
Impact of treatment with oral calcitriol on glucose indices in type 2 diabetes mellitus patients.
TLDR
Vitamin D supplementation attenuated the increase in glycemia, and increased insulin secretion, but had no effect on insulin resistance. Expand
Effects of vitamin D2 supplementation on insulin sensitivity and metabolic parameters in metabolic syndrome patients
TLDR
Vitamin D2 20,000 IU per week and 40,000IU per week givn for 8 weeks, were able to increase serum 25(OH)D concentrations significantly more than placebo group, however, HOMA-IR was not significantly different in the three groups. Expand
IMPROVEMENT IN PANCREATIC β-CELL FUNCTION WITH VITAMIN D AND CALCIUM SUPPLEMENTATION IN VITAMIN D-DEFICIENT NONDIABETIC SUBJECTS.
TLDR
Optizing serum 25-OHD concentrations and supplementation with calcium improves fasting plasma glucose levels and β-cell secretory reserve and larger randomized control studies are needed to determine if correction of 25- OHD deficiency will improve insulin secretion and prevent abnormalities of glucose homeostasis. Expand
Effect of cholecalciferol and levo carnitine on plasma glucose, plasma insulin and insulin resistance in type 2 diabetic rats.
TLDR
The combined supplementation of cholecalciferol and levo carnitine for 6 days markedly improved the glycaemic control, insulin secretion and insulin resistance in type 2 diabetic rats on high-fat diet. Expand
Vitamin D supplementation in diabetic patients
Background: Vitamin D supplementation was shown to reduce obesityrelated oxidative stress and inflammation among overweight or obese people as well as improving glycemic control and lipid profile inExpand
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TLDR
In a multiple linear regression analysis correcting for age, gender, and body mass index (BMI), the serum 25-hydroxyvitamin D level was significantly and positively associated with the ISI, whereas no association between measures of lean body mass were associated with insulin secretion or sensitivity. Expand
Effects of vitamin D on insulin and glucagon secretion in non-insulin-dependent diabetes mellitus.
TLDR
Vitamin D nutrition, or 1,25(OH)2D therapy, had no major effect on glucose homeostasis in non-insulin-dependent diabetes mellitus and was not related to indexes of mineral metabolism. Expand
Treatment with one-alpha-hydroxycholecalciferol in middle-aged men with impaired glucose tolerance--a prospective randomized double-blind study.
TLDR
A modest dose of active vitamin D, which did not cause elevation of serum calcium, did not provide general improvement of glucose tolerance or of insulin secretion when given to patients with impaired glucose tolerance, but without vitamin D deficiency, over a three-month period. Expand
Baseline Serum 25-Hydroxy Vitamin D Is Predictive of Future Glycemic Status and Insulin Resistance
TLDR
Inverse associations between baseline serum 25(OH)D and future glycemia and insulin resistance are reported, potentially important in understanding the etiology of abnormal glucose metabolism and warrant investigation in larger, specifically designed prospective studies and randomized controlled trials of supplementation. Expand
Long-term treatment with active vitamin D (alphacalcidol) in middle-aged men with impaired glucose tolerance. Effects on insulin secretion and sensitivity, glucose tolerance and blood pressure.
TLDR
Subjects with impaired glucose tolerance without vitamin D deficiency do not benefit from vitamin D supplementation, which however has some hypotensive action also in normotensive individuals. Expand
Calcium Is Essential in Normalizing Intolerance to Glucose That Accompanies Vitamin D Depletion In Vivo
TLDR
A time course of the calcium effect in vitamin D-depleted rats indicated that 7 days of high dietary calcium intake was needed to normalize GTT, with a significant correlation coefficient being observed between serum calcium and the maximum insulin response, suggesting that hypocalcemia predominates over vitamin D depletion in the glucose intolerance of vitamin D deficiency. Expand
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TLDR
A positive correlation of 25(OH)D concentration with insulin sensitivity and a negative effect of hypovitaminosis D on beta cell function are shown, which are at higher risk of insulin resistance and the metabolic syndrome. Expand
Vitamin D, glucose tolerance and insulinaemia in elderly men
TLDR
Vitamin D status was assessed in 142 elderly Dutchmen participating in a prospective population-based study of environmental factors in the aetiology of non-insulin-dependent diabetes mellitus andHypovitaminosis D may be a significant risk factor for glucose intolerance. Expand
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TLDR
It was found that 95% of at-risk and 80% of low-risk subjects were vitamin D deficient (serum 25-hydroxy-vitamin D <11 ng/ml) and the value of early and sustained repletion with vitamin D in diabetes prophylaxis should be examined in communities where vitamin D depletion is common. Expand
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TLDR
The results of this large prospective study suggest a potential beneficial role for both vitamin D and calcium intake in reducing the risk of type 2 diabetes. Expand
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