Supplementation with aged garlic extract improves both NK and γδ-T cell function and reduces the severity of cold and flu symptoms: a randomized, double-blind, placebo-controlled nutrition intervention.

@article{Nantz2012SupplementationWA,
  title={Supplementation with aged garlic extract improves both NK and $\gamma$$\delta$-T cell function and reduces the severity of cold and flu symptoms: a randomized, double-blind, placebo-controlled nutrition intervention.},
  author={Meri P. Nantz and Cheryl A. Rowe and Catherine E. Muller and Rebecca Creasy and Joy M. Stanilka and Susan S. Percival},
  journal={Clinical nutrition},
  year={2012},
  volume={31 3},
  pages={
          337-44
        }
}
View on PubMed
doi.org
87 Citations
Highly Influential Citations
4
Background Citations
37
Methods Citations
1
Results Citations
2

Figures and Tables from this paper

87 Citations

Aged Garlic Extract Modifies Human Immunity.
TLDR
It is suggested that AGE supplementation may enhance immune cell function and may be partly responsible for the reduced severity of colds and flu reported, and that the immune system functions well with AGE supplements, perhaps with less accompanying inflammation.
Aged garlic extract supplementation modifies inflammation and immunity of adults with obesity: A randomized, double-blind, placebo-controlled clinical trial.
Supplementation with a Natural Source of Amino Acids, Sil-Q1 (Silk Peptide), Enhances Natural Killer Cell Activity: A Redesigned Clinical Trial with a Reduced Supplementation Dose and Minimized Seasonal Effects in a Larger Population
TLDR
SQ is an effective and safe functional food supplement for enhancing immune function and considerable practical implications of SQ supplementation were showed.
The Effect of Kyolic Aged Garlic Extract on Gut Microbiota, Inflammation, and Cardiovascular Markers in Hypertensives: The GarGIC Trial
TLDR
Kyolic-aged-garlic-extract is effective in reducing blood pressure in patients with uncontrolled hypertension, and has the potential to improve arterial stiffness, inflammation, and gut microbial profile.
Immunomodulation and Anti-Inflammatory Effects of Garlic Compounds
The benefits of garlic to health have been proclaimed for centuries; however, only recently have Allium sativum and its derivatives been proposed as promising candidates for maintaining the…
Aged garlic extract suppresses inflammation in apolipoprotein E-knockout mice.
TLDR
The anti-atherosclerotic effect of AGE involves the suppression of inflammation by reducing the serum level of CRP and TXB2, and the protein level of TNF-α and IRAK4, and increasing AMPK activity in liver.
Does Flavonoid Consumption Improve Exercise Performance? Is It Related to Changes in the Immune System and Inflammatory Biomarkers? A Systematic Review of Clinical Studies since 2005
TLDR
It is suggested that flavonoids, especially anthocyanins, may exert beneficial effects for athletes’ performances, although further studies are encouraged to establish the optimal dosage and to clarify their impact on immune status.
Effects of fruit and vegetable consumption on inflammatory biomarkers and immune cell populations: a systematic literature review and meta-analysis.
TLDR
Higher intakes of fruit and vegetables lead to both a reduction in proinflammatory mediators and an enhanced immune cell profile, as suggested in a systematic review and meta-analysis.
The effects of twenty-four nutrients and phytonutrients on immune system function and inflammation: A narrative review
TLDR
Many nutrients and phytonutrients are capable of significantly modulating immune function and reducing inflammation, according to multiple biomarkers in clinical trials in different populations of adults with varying health statuses.
Potential Health Benefit of Garlic Based on Human Intervention Studies: A Brief Overview
TLDR
The present review aims to provide a comprehensive overview on the consumption of garlic, garlic preparation, garlic extract, and garlic extract-derived bioactive constituents on oxidative stress, inflammation, cancer, cardiovascular and metabolic disorders, skin, bone, and other common diseases.
...
...

References

SHOWING 1-10 OF 50 REFERENCES
Aged garlic extract prevents a decline of NK cell number and activity in patients with advanced cancer.
TLDR
It was showed that administering AGE to patients with advanced cancer of the digestive system improved NK cell activity, but caused no improvement in QOL, and both the number of NK cells and theNK cell activity increased significantly in the AGE group.
A short-term dietary supplementation with high doses of vitamin E increases NK cell cytolytic activity in advanced colorectal cancer patients
TLDR
It is demonstrated that vitamin E may boost NK cell function in patients with colorectal cancer by protecting from oxidative stress two weeks of high-dose treatment with the anti-oxidant vitamin E.
Galactooligosaccharide supplementation reduces stress-induced gastrointestinal dysfunction and days of cold or flu: a randomized, double-blind, controlled trial in healthy university students.
TLDR
Whether galactooligosaccharides (GOS) supplementation reduced GI dysfunction and percentage of days of cold/flu in academically stressed students and in healthy weight individuals was examined.
Bioactive Food Components that Enhance γδ T Cell Function May Play a Role in Cancer Prevention
TLDR
Research demonstrates that nutrients and bioactive food components can influence gammadelta T cell cytotoxicity, cytokine secretion, and proliferative capacity, and the results are nonetheless intriguing.
Select Plant Tannins Induce IL-2Rα Up-Regulation and Augment Cell Division in γδ T Cells1
TLDR
Using FACS-based assays, analyses suggest that a tannin-based drug may complement the phosphoantigen-based drugs, thereby enhancing the therapeutic potential of γδ T cells, and identified γ δ T cell agonists derived from the condensed tann in fractions of Uncaria tomentosa and Malus domestica.
Isolation, structural elucidation and immunomodulatory activity of fructans from aged garlic extract.
Preventing the common cold with a garlic supplement: A double-blind, placebo-controlled survey
TLDR
Volunteers in the active group were less likely to get a cold and recovered faster if infected, and an allicin-containing supplement can prevent attack by the common cold virus.
Polysaccharides derived from Yamoa (Funtumia elastica) prime gammadelta T cells in vitro and enhance innate immune responses in vivo.
Identification of the protein components displaying immunomodulatory activity in aged garlic extract.
In vitro glutathione supplementation enhances interleukin-2 production and mitogenic response of peripheral blood mononuclear cells from young and old subjects.
TLDR
GSH supplementation enhances T cell-mediated mitogenic response in young and old subjects and is due at least in part to decreased eicosanoid production.
...
...