Supplementation with Folic Acid during Methotrexate Therapy for Rheumatoid Arthritis: A Double-Blind, Placebo-Controlled Trial

  title={Supplementation with Folic Acid during Methotrexate Therapy for Rheumatoid Arthritis: A Double-Blind, Placebo-Controlled Trial},
  author={S. Morgan and J. Baggott and W. Vaughn and J. Austin and T. Veitch and J. Lee and W. Koopman and C. Krumdieck and G. Alarc{\'o}n},
  journal={Annals of Internal Medicine},
  • S. Morgan, J. Baggott, +6 authors G. Alarcón
  • Published 1994
  • Medicine
  • Annals of Internal Medicine
  • The folic acid antagonist methotrexate (n-10-methyl-aminopterin) is useful in low doses (2.5 to 20 mg/wk) for treating chronic inflammatory diseases [1-7]. Many trials have established the efficacy of methotrexate in rheumatoid arthritis [7-13]. Compared with other disease-modifying drugs, methotrexate has the highest probability of drug continuation at 10 years. Dose response-related toxic effects have been reported in 30% to 90% of patients given methotrexate [13]. Toxic effects include… CONTINUE READING
    330 Citations

    Paper Mentions

    Interventional Clinical Trial
    The aim of the this study is to evaluate the effectiveness of methotrexate added to treatment as usual on positive and negative symptoms, cognitive and social functioning and quality of… Expand
    ConditionsSchizoaffective Disorder, Schizophrenia, Schizophreniform Disorder
    Interventional Clinical Trial
    This study looks at how the arthritis drug methotrexate works in low doses to treat rheumatoid arthritis. (High doses of methotrexate are used to treat some types of cancer… Expand
    ConditionsAdjuvant Arthritis, Rheumatoid Arthritis
    InterventionDietary Supplement, Drug
    Methotrexate in Rheumatoid Arthritis
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