Supplementation of melatonin protects human lymphocytes in vitro from the genotoxic activity of melphalan.

@article{Lialiaris2008SupplementationOM,
  title={Supplementation of melatonin protects human lymphocytes in vitro from the genotoxic activity of melphalan.},
  author={Theodoros S Lialiaris and Emmanuel Lyratzopoulos and Fotini Papachristou and Mara Simopoulou and Constantinos Mourelatos and Nikolaos Nikolettos},
  journal={Mutagenesis},
  year={2008},
  volume={23 5},
  pages={347-54}
}
Melatonin (MLT) is a natural oncostatic factor of the human body as well as an antioxidant thus protects the nuclear DNA from oxidative damage. It also has the ability to reduce the side effects of various drugs when used as a combination therapy. The anti-neoplastic agent melphalan (MEL), which encompasses a number of side effects, is a strong alkylating agent and a potent inducer of sister chromatid exchanges (SCEs). The aim of the current in vitro study was to investigate the ability of MLT… CONTINUE READING