• Corpus ID: 44937217

Supplementation of male inhibitory material to lipid A activated human mononuclear cell supernatants contributes to the suppression of polymorphonuclear cell phagocytosis.

@article{Altamura1993SupplementationOM,
  title={Supplementation of male inhibitory material to lipid A activated human mononuclear cell supernatants contributes to the suppression of polymorphonuclear cell phagocytosis.},
  author={Maria Maddalena Altamura and Maria Assunta Potenza and M G Geronimo and Loredana Gandini and Claudio De Simone and Andrea Lenzi and Salvatore Antonaci and Emilio Jirillo},
  journal={Microbios},
  year={1993},
  volume={76 308},
  pages={
          181-7
        }
}
Human normal peripheral blood mononuclear cells were stimulated with lipid A (LA), the biologically active moiety of bacterial lipopolysaccharides. LA-activated supernatants were able to suppress polymorphonuclear cell (PMN) phagocytosis of Candida albicans. This inhibitory activity was enhanced by the supplementation of male inhibitory material (MIM) to active supernatants. The addition of a recombinant human anti-interleukin-1 beta monoclonal antibody to activated supernatants in the absence… 
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