Supplementation of lycopene attenuates lipopolysaccharide-induced amyloidogenesis and cognitive impairments via mediating neuroinflammation and oxidative stress.

@article{Wang2018SupplementationOL,
  title={Supplementation of lycopene attenuates lipopolysaccharide-induced amyloidogenesis and cognitive impairments via mediating neuroinflammation and oxidative stress.},
  author={Jia Wang and Lixia Li and Zhihua Wang and Yifan Cui and Xintong Tan and Tian Yuan and Qian Liu and Zhigang Liu and Xuebo Liu},
  journal={The Journal of nutritional biochemistry},
  year={2018},
  volume={56},
  pages={16-25}
}
Neuroinflammation is documented to be the major culprit of Alzheimer's disease. Lycopene (LYC), a fat soluble carotenoid, exhibits neuroprotective function in several neurodegenerative disorders. However, the effects of LYC to countering systemic inflammation-induced amyloidogenesis and memory deficiency remain to be elucidated. In current study, 3-month-old male C57BL/6J mice were treated with 0.03% LYC (w/w, mixed into normal chow) for 5 weeks. The mice were then treated by intraperitoneal… CONTINUE READING
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