Supplementation of creatine and ribose prevents apoptosis and right ventricle hypertrophy in hypoxic hearts.

  title={Supplementation of creatine and ribose prevents apoptosis and right ventricle hypertrophy in hypoxic hearts.},
  author={A. Caretti and P. Bianciardi and M. Marini and P. Abruzzo and A. Bolotta and Carlo Terruzzi and Franco Lucchina and M. Samaja},
  journal={Current pharmaceutical design},
  volume={19 39},
  • A. Caretti, P. Bianciardi, +5 authors M. Samaja
  • Published 2013
  • Biology, Medicine
  • Current pharmaceutical design
  • BACKGROUND/AIMS The simultaneous supplementation of creatine and D-ribose has been shown to reduce apoptosis in vitro in non-irreversibly injured cultured ischemic cardiomyocytes through down-regulation of the signaling mechanisms governing adenosine monophosphate-activated protein kinase (AMPK) and protein kinase B (Akt). Here, we test the hypothesis that an analogous mechanism exists in vivo when the challenge is chronic exposure to hypoxia. METHODS Five week-old mice were exposed to an… CONTINUE READING
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